缇庡ぉ鏃 | T缁嗚優婵€娲诲瑁呮惡绀煎墠鏉ワ紒

鍙戝竷鏃堕棿锛?022-06-28 09:32:00 浣滆€咃細

寰俊鍥剧墖_20220628093339.gif

涓烘劅鎭╁洖棣堟柊鑰佸鎴凤紝鍦ㄨ繖涓値鐐庡鏃ワ紝缇庡ぉ鏃嶵婵€娲诲瑁呮惡绀煎墠鏉ワ紝T缁嗚優鍒嗛€夌鐝犮€佹縺娲昏瘯鍓傘€佸煿鍏诲熀鍜岀粏鑳炲洜瀛愬洓澶х被鏄庢槦浜у搧锛屽姪鎮ㄩ珮鏁堟縺娲绘墿澧濼缁嗚優锛屽疄楠屼笉NG锛屾洿鏈夎秴鍊煎ソ绀间换鎮ㄩ€夈€侟/span>




鏄庢槦浜у搧涔婽缁嗚優婵€娲昏瘯鍓侟/span>


T Cell TransAct鈩㈡槸缇庡ぉ鏃庡熀浜庡厛杩涚殑绾崇背纾佺彔鐢熶骇宸ヨ壓锛屽湪绾崇背绾ц仛鍚堢墿鍩鸿川涓婂垎鍒伓鑱斾汉婧愬寲CD3銆丆D28鎶椾綋鐨勬柊鍨婽缁嗚優婵€娲昏瘯鍓傦紝楂樻晥妯℃嫙鎶楀師閫掑憟杩囩▼锛屽湪鍙潬婵€娲籘缁嗚優鐨勫悓鏃讹紝淇濇寔T缁嗚優鐨勯珮娲诲姏鍜屽厤鐤姛鑳姐€傚苟涓旈€氳繃绠€渚垮揩鎹风殑瀹為獙鏂规鍜岄厤濂楄瘯鍓傜粍鍚堬紝涓篢缁嗚優婵€娲绘墿澧炴彁渚涙渶澶х殑渚垮埄鎬у拰鍙噸澶嶆€с€侟/span>    

寰俊鍥剧墖_20220628093458.png

鍥?. T Cell TransAct鏈夋晥婵€娲籘缁嗚優锛屾縺娲绘晥鐜囦笌鍩轰簬寰背绾х鐝犵殑婵€娲昏瘯鍓傜浉褰撱€傚垎鍒敤T Cell TransAct鍜屽叾浠栦緵搴斿晢鍩轰簬纾佺彔鐨勬縺娲昏瘯鍓傛縺娲籘缁嗚優2澶╁悗锛屾祦寮忕粏鑳炴湳鍒嗘瀽娲诲寲鏍囧織鐗〤D69鍜孋D25鐨勮〃杈俱€侟/span>


寰俊鍥剧墖_20220628093531.jpg


鍥?. 琚玊 Cell TransAct婵€娲荤殑T缁嗚優鑳藉蹇€熸墿澧炪€俆缁嗚優鍒嗗埆鍦═exMACS鍩瑰吇鍩轰腑鐢═ Cell TransAct婵€娲伙紝鎴栨槸鍦≧PMI涓敤鍏朵粬渚涘簲鍟嗗熀浜庣鐝犵殑婵€娲昏瘯鍓傛縺娲伙紝鍩瑰吇14澶╁悗鐨勬墿澧炲€嶆暟鐩稿綋锛屼袱绉嶅煿鍏诲熀鍧囨坊鍔燤ACS浼樿川绾т汉IL-2 IS锛?0 U/mL锛夈€侟/span>



鐩告瘮鍩轰簬寰背绾х鐝犵殑婵€娲昏瘯鍓傦紝T Cell TransAct鈩㈡洿鏈夊涓嬮澶栦紭鍔匡細
1.绾崇背绾у井绮掞紝鎬ц川绋冲畾鍙潬
  • 涓嶆矇闄嶏紝鎮诞浜庡煿鍏诲熀涓紝鏇村潎鍖€鍦版帴瑙﹀拰婵€娲籘缁嗚優

  • 鍙繃婊ら櫎鑿岋紝鍙敓鐗╅檷瑙o紝鏃犺弻鏃犳瘨瀹颤/span>



寰俊鍥剧墖_20220628093601.png

鍥?. T Cell TransAct杩涜T缁嗚優鍒烘縺鏃跺湪缁嗚優鍩瑰吇浣撶郴涓浜庢偓娴姸鎬併€侟/span>



2.鍗崇敤鍨嬭瘯鍓傦紝鎿嶄綔绠€渚军/span>
  • 鏃犻渶棰勬竻娲楋紝鎸夋淮搴︾█閲婏紝鐩存帴浣跨敤锛岀渷鍘荤粏鑳炶鏁版楠|/span>

  • 鏃犻渶鐗规畩鐨勭鐝犲幓闄ゆ搷浣滃拰璁惧锛岃繃閲忚瘯鍓傞€氳繃绠€鍗曠殑绂诲績娓呮礂鍗冲彲鍘婚櫎

3.鏈夌浉搴旂殑MACS GMP绾т骇鍝侊紝鏃犵紳琛旀帴涓村簥鐮旂┒锛屽苟鍙湪CliniMACS Prodigy骞冲彴涓婂疄鐜板叏鑷姩鐨勭粏鑳炲鐞嗚繃绋嬨€侟/span>

闄や簡鍒涙柊鐨凾 Cell TransAct锛岀編澶╂棊涔熸彁渚涘熀浜庡井绫崇骇纾佺彔鐨勪汉T Cell Activation/Expansion kit锛屽寘鍚伓鑱旀姉鐢熺墿绱犳姉浣撶殑寰背绾ACSiBead鈩↑/span>纾佺彔鍜岀敓鐗╃礌鍖栫殑CD2銆丆D3銆丆D28鎶椾綋锛岄€氳繃灏員缁嗚優娲诲寲鎶椾綋璐熻浇鍒癕ACSiBead鈩↑/span>纾佺彔涓婏紝妯℃嫙鎶楀師閫掑憟缁嗚優锛岀‘淇濇湁鏁堢殑T缁嗚優浜よ仈涓庢椿鍖栥€侟/span>




鏄庢槦浜у搧涔婽缁嗚優鍒嗛€夌鐝燑/strong>
鍩轰簬绾崇背绾х鐝犲拰鍒嗛€夋煴鐨凪ACS缁嗚優鍒嗛€夛紝浣跨敤鏈€灏戦噺鐨勭鐝犳爣璁板嵆鍙幏寰楅珮绾害銆侀珮娲诲姏鐨勭洰鐨勭粏鑳烇紝鍚屾椂鎻愪緵澶氱鍒嗛€夌瓥鐣ユ弧瓒充笉鍚屽疄楠岄渶姹傦紝濡傞槼鎬у垎閫夋垨瀹屽叏鏃犳帴瑙︾殑闃存€у垎閫夈€侟/span>

鏄庢槦浜у搧涔婽缁嗚優鎵╁鍩瑰吇鍩裹/strong>
TexMACS鈩↑/span> GMP Medium鏄珮鎬ц兘鐨凾缁嗚優鎵╁瀹屽叏鍩瑰吇鍩猴紝涓撲负T缁嗚優鍩瑰吇浼樺寲锛屾弧瓒砊缁嗚優鍜岃皟鑺傛€缁嗚優鎵╁闇€姹傦紝鏃犺娓呫€佹棤鍔ㄧ墿婧愭垚鍒嗭紝绗﹀悎GMP鏍囧噯锛岄珮鎵归棿绋冲畾鎬э紝鎻愪緵瀹屾暣鍙拷婧枃浠躲€侟/span>
鏄庢槦浜у搧涔婞/span>浼樿川绾х粏鑳炲洜瀛忺/span>
閲囩敤鍥介檯鏍囧噯瀵规瘡涓€鎵规浜у搧鏍″噯鐢熺墿娲绘€э紝纭畾鍑嗙‘鐨勫崟浣嶅墏閲忥紝浣跨敤鏃舵棤闇€杩囬ケ鍜屾坊鍔狅紝纭繚瀹為獙缁撴灉鍙噸澶嶄笖鍙瘮銆傚浜嶵缁嗚優鎵╁锛岀編澶╂棊鏇存彁渚汭L-2鍜孖L-7+IL-15鐨勪袱绉嶄紭鍖栨柟妗堛€侷L-7鍜孖L-15鐨勭粍鍚堣兘澶熼伩鍏嶅洜涓鸿皟鑺傛€缁嗚優鎵╁瀵艰嚧鍓婂急鎶楄偪鐦ゅ厤鐤紝鍚屾椂鏇村埄浜庡共鎬у拰涓ぎ璁板繂T缁嗚優鐨勬墿澧炪€侟/span>


寰俊鍥剧墖_20220628093834.png

鍥?. 鐢═ Cell TransAct婵€娲荤殑T缁嗚優闅忓悗鐢↖L-7鍔營L-15鎵╁锛屽憟鐜版棭鏈熷垎鍖栬〃鍨嬶紝鎵╁14澶╁悗85%鐨勭粏鑳炰负骞叉€ц蹇員缁嗚優鍜屼腑澶蹇員缁嗚優銆侟/span>


寰俊鍥剧墖_20220628093912.jpg